Greater St. Louis Area: Key Projects & Developments
St. Louis City/County
- Downtown West Mixed-Use Development — A ~$232 M project near CityPark will include 450+ apartments, office and retail space, and a 29-story mass timber tower.
- Major Infrastructure & Road Projects — Ongoing MoDOT and county road improvements include bridge replacements on I-270, ADA sidewalk upgrades, resurfacing, and utility relocations across St. Louis County.
- Hospital & Health Facilities — Expansion work is underway for medical facilities such as new clinics and ambulatory care centers.
- Commercial & Retail Construction — New site development including an Aldi grocery store in Olivette and various mixed-use commercial projects across the county.
- Maryville University Hockey Center and other entertainment & cultural venue expansions in Chesterfield/Valley.
- Westport Plaza Redesign & Amenities — The Maryland Heights entertainment & retail district is undergoing improvements with public spaces, event use upgrades, and new attractions.
- Millennium Hotel Redevelopment — A major transformation of the long-vacant Millennium Hotel site near the Gateway Arch into a 1.3 million sq ft mixed-use destination with residential units, office space, public areas, events, and potentially housing the Arch National Park archives.
- New Residential Towers Downtown — Several proposed high-rise residential and mixed-use towers are planned, often with affordable housing components, contributing to a growing downtown skyline.
- Gateway South Innovation District — A multi-phase redevelopment of historic Chouteau’s Landing into a hub for design, construction, industrial, commercial, and future residential uses. It’s expected to begin operations with commercial and industrial tenants by 2026 and expand with more uses over time. Good Developments Group
- Powell Hall Expansion — The iconic home of the St. Louis Symphony Orchestra is underwent major upgrades to expand educational spaces, improve amenities, and enhance accessibility.
- America’s Center Convention Complex (AC Next Gen) — A significant expansion and modernization to support large-scale events.
- Saint Louis Zoo WildCare Park — A $230+ million conservation and experiential park in North County, with safari experiences, glamping, and animal habitats, planned to open around 2027.
- Next NGA West Campus — A $1.7+ billion National Geospatial-Intelligence Agency headquarters under construction, slated to open for employees in 2026, bringing workforce activity and investment downtown.
- Brickline Greenway — A major urban trail network connecting multiple neighborhoods and historic sites, projected for completion in 2030.
St. Charles County, Missouri
- Riverpointe Mixed-Use District (St. Charles) — A 120-acre riverfront redevelopment featuring residential, office, retail, hotel space, restaurants, entertainment, and community event spaces — one of the largest in St. Charles history.
- Kinetic Park – Phase 2 (Dardenne Prairie) — Expansion of a large community destination with family-oriented amenities and jobs.
- Streets of Caledonia (O’Fallon) — A major mixed-use development continuing to add retail, entertainment, and hospitality offerings.
- Mercy Hospital Wentzville Campus – Mercy has broken ground on a new hospital campus in Wentzville, set to be Missouri’s first newly built acute care hospital in nearly a decade.The project represents a $650 million investment covering ~400,000–425,000 sq ft and is being built on a 60-acre site near the I-70/I-64 interchange in western St. Charles County.It will feature 75 inpatient beds, a 26-bay emergency department (including trauma care), surgical suites, specialty care (cardiovascular, oncology, orthopedics), and outpatient diagnostic services. Construction began with site prep in early 2025 and is expected to complete by 2029. The campus is intended as a regional healthcare anchor, creating 1,000+ healthcare jobs and serving the rapidly growing western and northwestern suburbs.
- CenterPointe Hospital Renovation (St. Charles) – CenterPointe Hospital, a major behavioral health facility, is undergoing renovation and expansion, including a redesigned entrance/lobby, outpatient care spaces, and expanded parking to better serve patients and families in the region. Clayco
- Mercy Clinic Expansion in the Region – Mercy has expanded outpatient services in the area, including specialty clinics such as Mercy Kids Mid Rivers, offering pediatric care, behavioral health, and physical therapy spaces tailored to community health needs.
- St. Charles County and MoDOT have multiple ongoing infrastructure projects supporting growth and connectivity throughout the region:
- Highway improvements including US 61 West Outer Road extension, intersection signalization, and Pearce Blvd. signal upgrades.
- Mid Rivers Mall Drive corridor upgrades and Mexico Road bridge rehabilitation in St. Peters.
- I-70 corridor enhancements from Warrenton to Wentzville (including new interchanges, resurfacing, and bridge work
- I-64/I-70/US-61 interchange work and Boone Bridge rehabilitation to improve freight
- Cedarhurst Nursing Home (Wentzville) – recently completed senior care facility.
- Hampton Manor Assisted Living (O’Fallon) – under construction.
- Ignite Senior Living Facility (St. Peters) – in construction.
- SCC Regional Workforce & Technical Training Center (Wentzville) – institutional project under construction.
St. Charles City
- City Centre Complex – The city of St. Charles broke ground on the City Centre Complex, an ~$85 million civic and mixed-use development at the former American Car Foundry site. It will include a new city hall, senior center, indoor recreation facilities, an arts and culture space, food court, farmers market, and offices for non-profit partners.The City has several transportation and streetscape improvements in planning or early-stage design:
-
- Main Street Extension through the ACF site, including sidewalks, street lighting, and parking enhancements.
- North 2nd Street improvements with new sidewalks and ADA amenities slated for late-2026.
- Riverwalk (Katy Trail) enhancements—adding a separated walking and biking path, landscaping, and ADA upgrades.
- Pundmann Parkway Phase 2 and Regency Parkway reconstruction, improving connectivity and safety on key corridors.
- Lakeside Logistics Center & Rise St. Peters (Warehouses) – pre-construction industrial developments.
- Cambria Hotel (O’Fallon) – hospitality project underway.
- Automotive Point of Wentzville & Clement Auto Group (St. Charles) – automotive and related commercial developments.
- FedEx Logistics Facility & Commerce Park West (Dardenne Prairie) – logistics and industrial.
- Menards Retail (Wentzville) – new retail space pre-construction.
- St. Charles City Hall (Institutional) – new civic building pre-construction.
- Everhome Suites (St. Peters) and Woodsprings Suites (St. Peters) – hotel projects underway.
- Legacy Sports Complex (St. Charles) and O’Fallon Playfield Commons – pre-construction recreational projects.
- Ameristar Renovation (St. Charles) – entertainment venue revitalization.
- Multiple storage facility expansions across O’Fallon, St. Peters, and Wentzville.
- Manufacturing expansions including MEMC site work in O’Fallon.
Metro-East & Southern Illinois
- Orchard Town Center (Glen Carbon) — New retail additions including Dick’s Sporting Goods and other tenants under construction, expanding this 52-acre commercial hub.
- Film Studio Proposal (Wood River) — A proposed $62 M Hollywood River Studios project could bring sound stages, production space, and tech development to the region, pending approvals.
- Edwardsville Infrastructure Enhancements — A ~$4.87 M downtown project replacing century-old water mains and enhancing streetscape / ADA features, expected to complete mid-2026.
- East St. Louis Water Plant Upgrade — A recently completed ~$157 M modernization of the regional water treatment facility to improve capacity and sustainability.
- Alton Lovejoy Residential Project (Proposed) — A mixed-use/mixed-income housing development proposed by McCormack Baron Salazar, though still under review by localplanning officials.
- Ferry Expansion (Grafton-St. Charles) — A planned expansion of the Grafton ferry service to support tourism and commute access across the Mississippi River.
Other Regional Initiatives
- STL 2030 Progress Map Projects — Nearly 400 transformative developments and ~600 major infrastructure investments are tracked across the bi-state metro including transportation, housing, public spaces, etc. map.stl2030progress.com
- Affordable Housing & Urban Revitalization — Multifamily and workforce housing is emerging in Central City and Forest Park Southeast on the St. Louis side.
Greater St. Louis Area: Key Projects & Developments
St. Louis City/County
- Downtown West Mixed-Use Development — A ~$232 M project near CityPark will include 450+ apartments, office and retail space, and a 29-story mass timber tower.
- Major Infrastructure & Road Projects — Ongoing MoDOT and county road improvements include bridge replacements on I-270, ADA sidewalk upgrades, resurfacing, and utility relocations across St. Louis County.
- Hospital & Health Facilities — Expansion work is underway for medical facilities such as new clinics and ambulatory care centers.
- Commercial & Retail Construction — New site development including an Aldi grocery store in Olivette and various mixed-use commercial projects across the county.
- Maryville University Hockey Center and other entertainment & cultural venue expansions in Chesterfield/Valley.
- Westport Plaza Redesign & Amenities — The Maryland Heights entertainment & retail district is undergoing improvements with public spaces, event use upgrades, and new attractions.
- Millennium Hotel Redevelopment — A major transformation of the long-vacant Millennium Hotel site near the Gateway Arch into a 1.3 million sq ft mixed-use destination with residential units, office space, public areas, events, and potentially housing the Arch National Park archives.
- New Residential Towers Downtown — Several proposed high-rise residential and mixed-use towers are planned, often with affordable housing components, contributing to a growing downtown skyline.
- Gateway South Innovation District — A multi-phase redevelopment of historic Chouteau’s Landing into a hub for design, construction, industrial, commercial, and future residential uses. It’s expected to begin operations with commercial and industrial tenants by 2026 and expand with more uses over time. Good Developments Group
- Powell Hall Expansion — The iconic home of the St. Louis Symphony Orchestra is underwent major upgrades to expand educational spaces, improve amenities, and enhance accessibility.
- America’s Center Convention Complex (AC Next Gen) — A significant expansion and modernization to support large-scale events.
- Saint Louis Zoo WildCare Park — A $230+ million conservation and experiential park in North County, with safari experiences, glamping, and animal habitats, planned to open around 2027.
- Next NGA West Campus — A $1.7+ billion National Geospatial-Intelligence Agency headquarters under construction, slated to open for employees in 2026, bringing workforce activity and investment downtown.
- Brickline Greenway — A major urban trail network connecting multiple neighborhoods and historic sites, projected for completion in 2030.
St. Charles County, Missouri
- Riverpointe Mixed-Use District (St. Charles) — A 120-acre riverfront redevelopment featuring residential, office, retail, hotel space, restaurants, entertainment, and community event spaces — one of the largest in St. Charles history.
- Kinetic Park – Phase 2 (Dardenne Prairie) — Expansion of a large community destination with family-oriented amenities and jobs.
- Streets of Caledonia (O’Fallon) — A major mixed-use development continuing to add retail, entertainment, and hospitality offerings.
- Mercy Hospital Wentzville Campus – Mercy has broken ground on a new hospital campus in Wentzville, set to be Missouri’s first newly built acute care hospital in nearly a decade.The project represents a $650 million investment covering ~400,000–425,000 sq ft and is being built on a 60-acre site near the I-70/I-64 interchange in western St. Charles County.It will feature 75 inpatient beds, a 26-bay emergency department (including trauma care), surgical suites, specialty care (cardiovascular, oncology, orthopedics), and outpatient diagnostic services. Construction began with site prep in early 2025 and is expected to complete by 2029. The campus is intended as a regional healthcare anchor, creating 1,000+ healthcare jobs and serving the rapidly growing western and northwestern suburbs.
- CenterPointe Hospital Renovation (St. Charles) – CenterPointe Hospital, a major behavioral health facility, is undergoing renovation and expansion, including a redesigned entrance/lobby, outpatient care spaces, and expanded parking to better serve patients and families in the region. Clayco
- Mercy Clinic Expansion in the Region – Mercy has expanded outpatient services in the area, including specialty clinics such as Mercy Kids Mid Rivers, offering pediatric care, behavioral health, and physical therapy spaces tailored to community health needs.
- St. Charles County and MoDOT have multiple ongoing infrastructure projects supporting growth and connectivity throughout the region:
- Highway improvements including US 61 West Outer Road extension, intersection signalization, and Pearce Blvd. signal upgrades.
- Mid Rivers Mall Drive corridor upgrades and Mexico Road bridge rehabilitation in St. Peters.
- I-70 corridor enhancements from Warrenton to Wentzville (including new interchanges, resurfacing, and bridge work
- I-64/I-70/US-61 interchange work and Boone Bridge rehabilitation to improve freight
- Cedarhurst Nursing Home (Wentzville) – recently completed senior care facility.
- Hampton Manor Assisted Living (O’Fallon) – under construction.
- Ignite Senior Living Facility (St. Peters) – in construction.
- SCC Regional Workforce & Technical Training Center (Wentzville) – institutional project under construction.
St. Charles City
- City Centre Complex – The city of St. Charles broke ground on the City Centre Complex, an ~$85 million civic and mixed-use development at the former American Car Foundry site. It will include a new city hall, senior center, indoor recreation facilities, an arts and culture space, food court, farmers market, and offices for non-profit partners.The City has several transportation and streetscape improvements in planning or early-stage design:
-
- Main Street Extension through the ACF site, including sidewalks, street lighting, and parking enhancements.
- North 2nd Street improvements with new sidewalks and ADA amenities slated for late-2026.
- Riverwalk (Katy Trail) enhancements—adding a separated walking and biking path, landscaping, and ADA upgrades.
- Pundmann Parkway Phase 2 and Regency Parkway reconstruction, improving connectivity and safety on key corridors.
- Lakeside Logistics Center & Rise St. Peters (Warehouses) – pre-construction industrial developments.
- Cambria Hotel (O’Fallon) – hospitality project underway.
- Automotive Point of Wentzville & Clement Auto Group (St. Charles) – automotive and related commercial developments.
- FedEx Logistics Facility & Commerce Park West (Dardenne Prairie) – logistics and industrial.
- Menards Retail (Wentzville) – new retail space pre-construction.
- St. Charles City Hall (Institutional) – new civic building pre-construction.
- Everhome Suites (St. Peters) and Woodsprings Suites (St. Peters) – hotel projects underway.
- Legacy Sports Complex (St. Charles) and O’Fallon Playfield Commons – pre-construction recreational projects.
- Ameristar Renovation (St. Charles) – entertainment venue revitalization.
- Multiple storage facility expansions across O’Fallon, St. Peters, and Wentzville.
- Manufacturing expansions including MEMC site work in O’Fallon.
Metro-East & Southern Illinois
- Orchard Town Center (Glen Carbon) — New retail additions including Dick’s Sporting Goods and other tenants under construction, expanding this 52-acre commercial hub.
- Film Studio Proposal (Wood River) — A proposed $62 M Hollywood River Studios project could bring sound stages, production space, and tech development to the region, pending approvals.
- Edwardsville Infrastructure Enhancements — A ~$4.87 M downtown project replacing century-old water mains and enhancing streetscape / ADA features, expected to complete mid-2026.
- East St. Louis Water Plant Upgrade — A recently completed ~$157 M modernization of the regional water treatment facility to improve capacity and sustainability.
- Alton Lovejoy Residential Project (Proposed) — A mixed-use/mixed-income housing development proposed by McCormack Baron Salazar, though still under review by localplanning officials.
- Ferry Expansion (Grafton-St. Charles) — A planned expansion of the Grafton ferry service to support tourism and commute access across the Mississippi River.
Other Regional Initiatives
- STL 2030 Progress Map Projects — Nearly 400 transformative developments and ~600 major infrastructure investments are tracked across the bi-state metro including transportation, housing, public spaces, etc. map.stl2030progress.com
- Affordable Housing & Urban Revitalization — Multifamily and workforce housing is emerging in Central City and Forest Park Southeast on the St. Louis side.
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